4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

Base Information

Chemical Name:4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide
CAS No.:1372262-45-7
Molecular Formula:C₂₉H₃₆N₈O₄S
Molecular Weight:592.722
Hs Code.:

Synonyms:4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

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Chemical Property of 4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

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Technology Process of 4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

There total 11 articles about 4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372262-49-1
4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

: 1372262-45-7
4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; ethylenediamine; In tetrahydrofuran; at 80 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1372262-45-7
4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: ammonia; methanol / Ra-Ni / 4 h / 20 °C / 1551.49 Torr

3: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

4: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

5: hydrogenchloride; sodium hydroxide / water; methanol / 20 °C / pH 5

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

7: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; methanol; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; caesium carbonate; ethylenediamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4: Buchwald-Hartwig coupling;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372262-45-7
4-{[4-({2-[methyl(methylsulfonyl)amino]benzyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-(3-morpholin-4-ylpropyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

4.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

5.1: hydrogenchloride; sodium hydroxide / water; methanol / 20 °C / pH 5

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; ethylenediamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4.1: Buchwald-Hartwig coupling;