2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE

Base Information

• Chemical Name: 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE
• CAS No.: 91591-59-2
• Molecular Formula: C9H10 N2 O
• Molecular Weight: 162.191
• Hs Code.: 2933399990
• Mol file: 91591-59-2.mol

Synonyms:1,2-Dihydro-4,5,6-trimethyl-2-oxo-3-pyridinecarbonitrile

Chemical Property of 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE

Chemical Property:

• Vapor Pressure: 0.000125mmHg at 25°C
• Boiling Point: 334.8°C at 760 mmHg
• Flash Point: 156.3°C
• PSA: 56.91000
• Density: 1.12g/cm³
• LogP: 1.58408

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-4,5,6-trimethylnicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE

There total 1 articles about 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetylacetone (123-54-6,81235-32-7) + cyanoacetic acid amide (107-91-5) → 3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) + 4,5,6-trimethyl-2 -oxo-1,2-dihydropyridine-3-carbonitrile (91591-59-2)

Guidance literature:

Reference yield: 93.0%

4,5,6-trimethyl-2 -oxo-1,2-dihydropyridine-3-carbonitrile (91591-59-2) → 2-chloro-4,5,6-trimethylpyridine-3-carbonitrile (91591-64-9)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 15h;

Reference yield:

2-hydroxy-4,5,6-trimethyl-nicotinonitrile (91591-59-2) → 2,3,4,5-tetramethyl pyridine (18441-60-6)

Guidance literature:

Multi-step reaction with 5 steps

1: PCl₅ / 180 °C

2: palladium/CaCO₃; methanol / Hydrogenation

3: hydrochloric acid; sodium nitrite; water

4: thionyl chloride

5: palladium/calcium carbonate; methanol / Hydrogenation

With hydrogenchloride; methanol; palladium on activated charcoal; Lindlar's catalyst; thionyl chloride; phosphorus pentachloride; water; sodium nitrite;

upstream raw materials:

acetylacetone

cyanoacetic acid amide

Downstream raw materials:

2-chloro-4,5,6-trimethylpyridine-3-carbonitrile

2,3,4-lutidine

6-chloro-2,3,4-trimethyl-pyridine

2,3,4,5-tetramethyl pyridine

Refernces

• 1、 -. "Herbicidal cyclohexane-1,3-dione derivatives". . . Retrieved 2008/06/13.