Benazeprilat Ethyl tert-Butyl Diester

Base Information

• Chemical Name: Benazeprilat Ethyl tert-Butyl Diester
• CAS No.: 859635-53-3
• Molecular Formula: C₂₈H₃₆N₂O₅
• Molecular Weight: 480.604
• Mol file: 859635-53-3.mol

Synonyms:3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester

Chemical Property of Benazeprilat Ethyl tert-Butyl Diester

Chemical Property:

• Boiling Point: 651.7±55.0 °C(Predicted)
• PKA: 4.83±0.20(Predicted)
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig

Purity/Quality:

BenazeprilatEthyltert-ButylDiester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benazeprilat Ethyl tert-Butyl Diester is an analog of Benazepril (B119750).

Technology Process of Benazeprilat Ethyl tert-Butyl Diester

There total 1 articles about Benazeprilat Ethyl tert-Butyl Diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester bis-(D)-tartrate salt → 3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester (859635-53-3)

Guidance literature:

With water; potassium carbonate; In ethyl acetate; at 20 ℃;

Reference yield:

3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester (859635-53-3) → benazepril hydrochloride (86541-74-4,215447-89-5,88372-38-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 2 - 3h;

Reference yield:

3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester (859635-53-3) + isopropylmalonic acid (601-79-6) → 3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester bis-isopropylmalonate salt

Guidance literature:

In ethyl acetate; Heating / reflux;

Downstream raw materials:

benazepril hydrochloride

Refernces