2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

Base Information

Chemical Name:2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt
CAS No.:1122489-87-5
Molecular Formula:C₆H₁₅N*C₃₆H₅₉N₇O₉SSi₂
Molecular Weight:923.335
Hs Code.:

Synonyms:2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

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Chemical Property of 2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

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Technology Process of 2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

There total 1 articles about 2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 863238-53-3
2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine

: 121-44-8
triethylamine

: 3674-06-4
Boc-Phe-ONSu

: 1122489-87-5
2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

Guidance literature:: 2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine; Boc-Phe-ONSu; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Cooling with ice;

triethylamine; With silica gel; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2008.11.054

Reference yield: 44.0%

: 1122489-87-5
2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

: 121-44-8
triethylamine

: 1122489-93-3
5'-O-[N-(L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

Guidance literature:: 2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt; With trifluoroacetic acid; In water; at 20 ℃; for 1.5h; Inert atmosphere;

triethylamine; In ethanol;

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2008.11.054

Reference yield:

: 1122489-87-5
2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

: 121-44-8
triethylamine

: 1122489-91-1
2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt

Guidance literature:: 2',3'-di-O-(tert-butyldimethylsilyl)-5'-O-[N-(N-Boc-L-phenylalanyl)-sulfamoyl]adenosine triethylamine salt; With trifluoroacetic acid; In water; at 20 ℃; for 2h; Inert atmosphere;

triethylamine; In ethanol;
DOI:10.1016/j.bmc.2008.11.054