2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

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Chemical Name:2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione
CAS No.:1199557-03-3
Molecular Formula:C₃₅H₂₅F₂N₅O₃
Molecular Weight:601.612
Hs Code.:

Synonyms:2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

There total 10 articles about 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1199557-02-2
7-chloro-1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridine

: 1199556-90-5
2-{trans-3-hydroxy-3-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}-1H-isoindole-1,3(2H)-dione

: 1199557-03-3
2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 140 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1199557-05-5
tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

: 1199557-03-3
2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / 1 h / 20 °C

2: triethylamine / chloroform / 70 °C

3: toluenesulfonic acid monohydrate / acetone / 48 h / Reflux

4: tetrahydrofuran; dichloromethane / 1 h / -20 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 3 h / 80 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; dimethyl sulfoxide; acetone;

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 1199557-03-3
2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / chloroform / 70 °C

2: toluenesulfonic acid monohydrate / acetone / 48 h / Reflux

3: tetrahydrofuran; dichloromethane / 1 h / -20 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 3 h / 80 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With potassium acetate; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; dimethyl sulfoxide; acetone;