trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

Base Information

Chemical Name:trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol
CAS No.:1199556-40-5
Molecular Formula:C₂₇H₂₃F₂N₅O
Molecular Weight:471.509
Hs Code.:

Synonyms:trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

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Chemical Property of trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

Chemical Property:

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Technology Process of trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

There total 10 articles about trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1199557-03-3
2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione

: 1199556-40-5
trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

Guidance literature:: With hydrazine hydrate; In ethanol; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1199557-05-5
tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

: 1199556-40-5
trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid / 1 h / 20 °C

2: triethylamine / chloroform / 70 °C

3: toluenesulfonic acid monohydrate / acetone / 48 h / Reflux

4: tetrahydrofuran; dichloromethane / 1 h / -20 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 3 h / 80 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

7: hydrazine hydrate / ethanol / 0.5 h / 120 °C / Microwave irradiation

With potassium acetate; sodium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; acetone;

Reference yield:

: 1199557-04-4
tert-butyl (6-chloro-2-formylpyridin-3-yl)carbamate

: 1199556-40-5
trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 100 °C

2: hydrazine hydrate / pyridine / 1.5 h / 160 °C / Microwave irradiation

3: Difluoroacetic acid / MDI / 1 h / 200 °C / Microwave irradiation

4: trichlorophosphate / acetonitrile / 2 h / 140 °C / Microwave irradiation

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

6: hydrazine hydrate / ethanol / 0.5 h / 120 °C / Microwave irradiation

With Difluoroacetic acid; sodium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; MDI; acetonitrile;