benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate

Base Information

• Chemical Name: benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate
• CAS No.: 143673-60-3
• Molecular Formula: C₂₈H₂₄N₂O₇
• Molecular Weight: 500.508
• Mol file: 143673-60-3.mol

Synonyms:benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate

Chemical Property of benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate

There total 3 articles about benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

benzyl L-2-benzyloxycarbonylamino-5-chloro-4-oxopentanoate (50817-15-7) + potassium phtalimide (1074-82-4) → benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate (143673-60-3)

Guidance literature:

In N,N-dimethyl-formamide; at 40 - 45 ℃; for 1h;

Reference yield:

N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester (64578-11-6) → benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate (143673-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 12 h / -78 °C

2: 51 percent / HCl / CHCl₃; diethyl ether / 0.08 h / 0 °C

3: 59 percent / dimethylformamide / 1 h / 40 - 45 °C

With hydrogenchloride; In diethyl ether; chloroform; N,N-dimethyl-formamide;

Reference yield:

benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate (50930-59-1) → benzyl L-2-benzyloxycarbonylamino-4-oxo-5-phthalimidopentanoate (143673-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / HCl / CHCl₃; diethyl ether / 0.08 h / 0 °C

2: 59 percent / dimethylformamide / 1 h / 40 - 45 °C

With hydrogenchloride; In diethyl ether; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

benzyl L-2-benzyloxycarbonylamino-5-chloro-4-oxopentanoate

potassium phtalimide

N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester

benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate

Downstream raw materials:

(2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid

L-histidine