(E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide

Base Information

• Chemical Name: (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide
• CAS No.: 1453190-45-8
• Molecular Formula: C₃₆H₃₆N₂O₆
• Molecular Weight: 592.692
• Mol file: 1453190-45-8.mol

Synonyms:(E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide

Chemical Property of (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide

There total 4 articles about (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C40H40N2O8 → (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide (1453190-45-8)

Guidance literature:

With methanol; sodium methylate; for 1h; Reflux;

DOI:10.1016/j.tetlet.2013.07.134

Reference yield:

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid (2596-47-6,147677-05-2,34749-55-8) → (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide (1453190-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / Reflux; Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

3: sodium methylate; methanol / 1 h / Reflux

With methanol; thionyl chloride; sodium methylate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2013.07.134

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-diphenethylacrylohydrazide (1453190-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Cooling with ice; Inert atmosphere

2: acetyl chloride; methanol / 18 h / 0 - 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

4: sodium methylate; methanol / 1 h / Reflux

With methanol; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; acetyl chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.07.134

upstream raw materials:

1-phenyl-2-bromoethane

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid

di-tert-butyl 1,2-bis(2-phenylethyl)hydrazine-1,2-dicarboxylate