2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

Base Information

Chemical Name:2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile
CAS No.:1403381-97-4
Molecular Formula:C₁₉H₁₉NO₂
Molecular Weight:293.365
Hs Code.:

Synonyms:2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

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Chemical Property of 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

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Technology Process of 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

There total 4 articles about 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 7677-24-9
trimethylsilyl cyanide

: 1403381-96-3
2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethyl benzaldehyde

: 1403381-97-4
2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 95-87-4
2,5-Dimethylphenol

: 1403381-97-4
2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 0.25 h / 20 °C

1.2: 20 h / 80 °C

2.1: dmap; triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 80 °C / irradiated 200W

4.1: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; sodium carbonate; triethylamine; zinc(II) iodide; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1666-04-2
2-hydroxy-3,6-dimethylbenzaldehyde

: 1403381-97-4
2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 80 °C / irradiated 200W

3: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; sodium carbonate; triethylamine; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene;