2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile
CAS No.:1201645-40-0
Molecular Formula:C₃₁H₂₆N₄O
Molecular Weight:470.574
Hs Code.:

Synonyms:2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Chemical Property:

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Technology Process of 2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

There total 13 articles about 2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1201645-39-7
2-(4-((3-nitro-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 1201645-40-0
2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 2h;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-40-0
2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

9.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 12 h / Inert atmosphere; Reflux

10.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 9.1: Suzuki Coupling;

Reference yield:

: 1201643-78-8
2-(4-(5-bromo-1-tosyl-1H-indol-3-carbonyl)phenyl)-2-methylpropanenitrile

: 1201645-40-0
2-(4-((3-amino-6-(6-phenoxypyridin-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5: hydrogenchloride / acetone / 24 h

6: hydrogenchloride / water / 24 h

7: potassium acetate / ethanol / 5 h / Reflux

8: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

9: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 12 h / Inert atmosphere; Reflux

10: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 9: Suzuki Coupling;