{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

Base Information

Chemical Name:{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester
CAS No.:735270-11-8
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

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Chemical Property of {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

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Technology Process of {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

There total 10 articles about {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 735270-09-4
{2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-carbamic acid benzyl ester

: 735270-11-8
{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

Guidance literature:: With sulfuric acid; In water; acetone; for 24h; Heating;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 61330-09-4
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate

: 735270-11-8
{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 89 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Heating

2.1: 87 percent / NaCl; H₂O / dimethylsulfoxide / 6 h / 140 °C

3.1: 95 percent / PPTS / benzene / 3 h / Heating

4.1: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

5.1: 82 percent / NaNH₂ / diethyl ether; tetrahydrofuran / 0.17 h / 0 °C

6.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

6.2: 75 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O

7.1: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

8.1: tetrahydrofuran; H₂O / 2 h / 80 °C

9.1: 88 percent / K₂CO₃ / 4 h / 0 - 20 °C

10.1: 85 percent / H₂SO₄ / acetone; H₂O / 24 h / Heating

With dimethylsulfide borane complex; sulfuric acid; water; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; sodium amide; triethylamine; sodium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetone; benzene; 1.1: Dieckmann condensation / 2.1: Krapcho's demethoxycarbonylation / 5.1: Wittig reaction;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 51533-65-4
4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone

: 735270-11-8
{2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 95 percent / PPTS / benzene / 3 h / Heating

2.1: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 82 percent / NaNH₂ / diethyl ether; tetrahydrofuran / 0.17 h / 0 °C

4.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

4.2: 75 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O

5.1: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6.1: tetrahydrofuran; H₂O / 2 h / 80 °C

7.1: 88 percent / K₂CO₃ / 4 h / 0 - 20 °C

8.1: 85 percent / H₂SO₄ / acetone; H₂O / 24 h / Heating

With dimethylsulfide borane complex; sulfuric acid; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; sodium amide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; benzene; 3.1: Wittig reaction;
DOI:10.1016/j.tetlet.2004.05.021