61330-09-4

Basic information

• Product Name: dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate
• Synonyms: dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate
• CAS NO: 61330-09-4
• Molecular Formula: C₁₈H₂₃NO₆
• Molecular Weight: 349.37832
• Mol File: 61330-09-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate(61330-09-4)
• EPA Substance Registry System: dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate(61330-09-4)

Safety Data

• Hazardous Substances Data: 61330-09-4(Hazardous Substances Data)

Usage

Preparation

Dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate can be prepared by the following steps:A mixture of finely powdered 3,4- dimethoxyphenylacetonitrile 45 (5 g, 28.25 mmol) and ?TBAHSO4 (0.096 g, 0.28 mmol) in 10% aq. NaOH ?solution (20 ml) was stirred for 30 minutes at room ?temperature. A dark red colour appeared. The mixture was ?then cooled in an ice-bath. Methyl acrylate 239 was slowly ?added dropwise at 0 o C, (12.65 ml, 138.95 mmol). After 1 hour a colourless solid was ?formed, which was filtered and crystallized from EtOAc (7.49 g, 76% yield). ? Alternatively, dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate was prepared by refluxing a mixture of 3,4- dimethoxyphenylacetonitrile (100 g, 0.564 mol) and methyl acrylate (253 ml, 2.82 mol) in ?the presence of Triton-B (2.35 ml, 0.006 mol, 40% solution in MeOH) in CH3CN for ?overnight in almost quantitative yields (197 g).

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 292638-85-8 acrylic acid methyl ester 
• 100-85-6 N-benzyl-trimethylammonium hydroxide 
• 127581-20-8 4-cyano-4-(3,4-dimethoxy-phenyl)-heptanedinitrile 

Downstream Products

• 51533-65-4 4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone 
• 735269-96-2 5-cyano-5-(3,4-dimethoxy-phenyl)-2-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 6023-73-0 mesembrine 
• 735270-01-6 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde 
• 735270-03-8 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-9-vinyl-1,5-dioxa-spiro[5.5]undecane 
• 735269-99-5 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbonitrile 
• 735270-05-0 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethanol 
• 735270-07-2 {2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-amine 
• 735270-17-4 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-19-6 methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester 
• 735270-11-8 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-15-2 {2-[3-bromo-1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-13-0 {2-[1-(3,4-dimethoxy-phenyl)-4-trimethylsilanyloxy-cyclohex-3-enyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-09-4 {2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-carbamic acid benzyl ester 

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