di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

Base Information

Chemical Name:di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate
CAS No.:934424-08-5
Molecular Formula:C₂₆H₃₁N₃O₅
Molecular Weight:465.549
Hs Code.:

Synonyms:di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

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Chemical Property of di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

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Technology Process of di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

There total 4 articles about di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 934423-97-9
2-((E)-1-iodo-2-(4-methoxyphenyl)vinyl)benzonitrile

: 16466-61-8
1,2-bis(t-butyloxycarbonyl)hydrazine

: 934424-08-5
di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 13h;
DOI:10.1021/ol062978s

Reference yield:

: 4387-36-4
2-iodobenzonitrile

: 934424-08-5
di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 60 °C

2.1: Bu₃SnH / PdCl₂(PPh₃)2 / tetrahydrofuran / 1.5 h / 20 °C

2.2: 79 percent / I₂ / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: 95 percent / CuI; 1,10-phenanthroline; Cs₂CO₃ / dimethylformamide / 13 h / 80 °C

With copper(l) iodide; 1,10-Phenanthroline; tri-n-butyl-tin hydride; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol062978s

Reference yield:

: 768-60-5
4-methoxyphenylacetylen

: 934424-08-5
di(tert-butyl) 1-[(E)-1-(2-cyanophenyl)-2-(4-methoxyphenyl)ethenyl]-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 60 °C

2.1: Bu₃SnH / PdCl₂(PPh₃)2 / tetrahydrofuran / 1.5 h / 20 °C

2.2: 79 percent / I₂ / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: 95 percent / CuI; 1,10-phenanthroline; Cs₂CO₃ / dimethylformamide / 13 h / 80 °C

With copper(l) iodide; 1,10-Phenanthroline; tri-n-butyl-tin hydride; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol062978s