2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

Base Information

Chemical Name:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid
CAS No.:113976-26-4
Molecular Formula:C₂₇H₃₆N₈O₅
Molecular Weight:552.633
Hs Code.:

Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

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Chemical Property of 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

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Technology Process of 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

There total 6 articles about 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 113976-34-4
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid dimethyl ester

: 113976-26-4
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1021/jm00402a014

Reference yield:

: 3903-40-0
12-methoxy-12-oxododecanoic acid

: 113976-26-4
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / dimethylformamide / 3 h / Heating

2: Br₂, I₂ / SOCl₂; dimethylformamide / 4 h / Irradiation

3: 3.5 h / Ambient temperature

4: NaN₃ / ethanol / 15 h / Heating

5: H₂, aq. HCl / Pd-C / ethanol / 17 h

6: 67 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 76 h / Ambient temperature

7: 100 percent / aq. NaOH / methanol

With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; diethyl cyanophosphonate; hydrogen; bromine; iodine; triethylamine; palladium on activated charcoal; In methanol; thionyl chloride; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a014

Reference yield:

: 113976-41-3
α-Brom-dodecandisaeure-dimethylester

: 113976-26-4
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-dodecanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaN₃ / ethanol / 15 h / Heating

2: H₂, aq. HCl / Pd-C / ethanol / 17 h

3: 67 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 76 h / Ambient temperature

4: 100 percent / aq. NaOH / methanol

With hydrogenchloride; sodium hydroxide; sodium azide; diethyl cyanophosphonate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a014