2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

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Chemical Name:2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one
CAS No.:1018678-56-2
Molecular Formula:C₂₄H₂₂F₃N₃O₂
Molecular Weight:441.453
Hs Code.:

Synonyms:2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

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Chemical Property of 2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

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Technology Process of 2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

There total 4 articles about 2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255648-40-8
C₁₂H₁₃F₃N₂O₄

: 1018678-56-2
2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol

2: N,N-dimethyl-formamide

3: toluene-4-sulfonic acid / toluene

With hydrogenchloride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo302515c

Reference yield:

: 4-iodo-2-(trifluoromethyl)pyridine-2-carboxylic acid

: 1018678-56-2
2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol

2: hydrogenchloride / methanol

3: N,N-dimethyl-formamide

4: toluene-4-sulfonic acid / toluene

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; tert-Amyl alcohol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo302515c

Reference yield:

: 1255648-38-4
C₇H₅F₃N₂O₂*ClH

: 1018678-56-2
2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide

2: toluene-4-sulfonic acid / toluene

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo302515c