(R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide

Base Information

• Chemical Name: (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide
• CAS No.: 1018678-55-1
• Molecular Formula: C₁₆H₁₆F₃N₃O
• Molecular Weight: 323.318
• Mol file: 1018678-55-1.mol

Synonyms:(R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide

Chemical Property of (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide

There total 5 articles about (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-amino-2-trifluoromethyl-nicotinic acid (1018678-42-6) + (-)-Amphetamine hydrochloride (41820-21-7,405-41-4) → (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide (1018678-55-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-amino-2-trifluoromethyl-nicotinic acid (1018678-42-6) + l-amphetamine (156-34-3,17108-96-2,96332-84-2) → (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide (1018678-55-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2009.07.004

Reference yield:

4-iodo-2-(trifluoromethyl)pyridine-2-carboxylic acid → (R)-4-amino-N-(1-phenylpropan-2-yl)-2-(trifluoromethyl)nicotinamide (1018678-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol

2: hydrogenchloride / methanol

3: N,N-dimethyl-formamide

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; tert-Amyl alcohol; N,N-dimethyl-formamide;

DOI:10.1021/jo302515c

upstream raw materials:

4-amino-2-trifluoromethyl-nicotinic acid

(-)-Amphetamine hydrochloride

l-amphetamine

C₇H₅F₃N₂O₂*ClH

Downstream raw materials:

2-(2-methoxyphenyl)-3-((R)-1-phenylpropan-2-yl)-5-(trifluoromethyl)-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one