N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

Base Information

Chemical Name:N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide
CAS No.:942509-19-5
Molecular Formula:C₂₀H₂₅NO₃S
Molecular Weight:359.489
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

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Technology Process of N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

There total 1 articles about N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 59724-52-6
N-mesitylenesulfonyl ethanolamine

: 4392-24-9
Cinnamyl bromide

: 942509-19-5
N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jo0700528

Reference yield:

: 942509-19-5
N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

: 1026910-12-2
C₂₀H₂₃SO₃N

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1021/jo0700528

Reference yield:

: 942509-19-5
N-(2-hydroxyethyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

: 867297-15-2
N-(buta-2,3-dienyl)-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; SO₃*Py / dimethylsulfoxide / 1 h / 20 °C

2: 1.47 g / CHCl₃ / 15 h / 20 °C

3: 85 percent / DIBAL-H / CH₂Cl₂; hexane / 1 h / 0 °C

4: Et₃N / tetrahydrofuran / 1 h / 0 °C

5: 270 mg / diethylzinc / Pd(PPh₃)4 / tetrahydrofuran; hexane / 1 h / 20 °C

With pyridine-SO₃ complex; diethylzinc; diisobutylaluminium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; chloroform; dimethyl sulfoxide; 2: Wittig olefination;
DOI:10.1021/jo0700528