N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide

Base Information

• Chemical Name: N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide
• CAS No.: 18313-03-6
• Molecular Formula: C8H6 Cl2 N2 O2
• Molecular Weight: 233.054
• DSSTox Substance ID: DTXSID50425123
• Mol file: 18313-03-6.mol

Synonyms:N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide;18313-03-6;N-(2,4-Dichlorophenyl)-2-(hydroxyimino)acetamide;N1-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide;Maybridge1_007247;SCHEMBL3074427;DTXSID50425123;FT-0629648

Chemical Property of N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide

Chemical Property:

• Melting Point: 198 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 61.69000
• Density: 1.49g/cm³
• LogP: 2.46490
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 231.9806328
• Heavy Atom Count: 14
• Complexity: 235

Purity/Quality:

98%min ^*data from raw suppliers

N1-(2,4-DICHLOROPHENYL)-2-HYDROXYIMINOACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)NC(=O)C=NO

Technology Process of N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide

There total 3 articles about N-(2,4-dichlorophenyl)-2-hydroxyiminoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloral hydrate (302-17-0) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → N-(α-Oximino-acetyl)-2.4-dichlor-anilin (18313-03-6)

Guidance literature:

2,4-Dichloroaniline; With hydrogenchloride; In water;

chloral hydrate; With sodium sulfate; In water; at 20 ℃; for 0.5h;

With hydroxylamine hydrochloride; In water; at 70 ℃;

DOI:10.1021/acschemneuro.0c00448

Reference yield:

acetic acid acetoxy-(2,4-dichloro-phenylcarbamoyl)-methyl ester → N-(α-Oximino-acetyl)-2.4-dichlor-anilin (18313-03-6)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; for 2h; Heating;

DOI:10.1016/j.tetlet.2005.10.046

Reference yield:

→ N-(α-Oximino-acetyl)-2.4-dichlor-anilin (18313-03-6)

Guidance literature:

2.4-Dichlor-anilin, Chloralhydrat, Hydroxylamin, in ges. Lsg. von Na2SO4 in wss. HCl;

upstream raw materials:

chloral hydrate

2,4-Dichloroaniline

Downstream raw materials:

5,7-dichloroisatin

Refernces

• 1、 Rewcastle, Gordon W.,Sutherland, Hamish S.,Weir, Claudette A.,Blackburn, Adrian G.,Denny, William A.. "An improved synthesis of isonitrosoacetanilides". . p. 8719 - 8721. Retrieved 2007/10/03.