(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

Base Information

Chemical Name:(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide
CAS No.:1370705-48-8
Molecular Formula:C₁₅H₁₆ClF₃N₄O₄S
Molecular Weight:440.831
Hs Code.:

Synonyms:(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

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Chemical Property of (R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

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Technology Process of (R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

There total 3 articles about (R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1391150-82-5
C₁₄H₁₈ClF₃N₄O₄S

: 149-73-5
trimethyl orthoformate

: 1370705-48-8
(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

Guidance literature:: With boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 23 - 70 ℃; for 12h;
DOI:10.1021/jm300094u

Reference yield:

: 1146699-67-3
(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide

: 1370705-48-8
(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 23 - 80 °C

2: hydroxylamine / ethanol; water / 1 h / 23 - 80 °C

3: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 12 h / 23 - 70 °C

With boron trifluoride diethyl etherate; hydroxylamine; caesium carbonate; In ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300094u

Reference yield:

: 1370705-42-2
(R)-2-[4-chloro-N-(2-cyanoethyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

: 1370705-48-8
(R)-2-{N-[2-(1,2,4-oxadiazol-3-yl)ethyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / ethanol; water / 1 h / 23 - 80 °C

2: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 12 h / 23 - 70 °C

With boron trifluoride diethyl etherate; hydroxylamine; In ethanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm300094u