tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

Base Information

Chemical Name:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate
CAS No.:1428935-41-4
Molecular Formula:C₃₉H₄₉N₅O₉S
Molecular Weight:768.872
Hs Code.:

tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

Synonyms:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

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Chemical Property of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

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Technology Process of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

There total 11 articles about tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1232423-98-1
tert-butyl N-(3-ethynyl-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)N-tertbutoxycarbonyl-carbamate ?

: 1428935-40-3
tert-butyl N-[[4-[chloro-N-hydroxycarbonimidoyl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

: 1428935-41-4
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 65 ℃; for 3.5h;

Reference yield:

: 1428935-59-4
C₉H₁₂BrN₃Si*C₇H₈O₃S

: 1428935-41-4
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogencarbonate / water; ethyl acetate / 0.5 h

1.2: 0.5 h

1.3: charcoal (Darco G-60); Celite / 2 h

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 3.5 h / 65 °C

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1428935-41-4
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-(trideuteriomethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 3.5 h / 65 °C

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; water; acetonitrile;