(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Base Information

Chemical Name:(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol
CAS No.:1556953-96-8
Molecular Formula:C₁₉H₂₄FNO₃
Molecular Weight:333.403
Hs Code.:

Synonyms:(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Suppliers and Price of (R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

There total 10 articles about (R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1142232-56-1
(R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

: 1556953-96-8
(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml4005123

Reference yield:

: 1142232-39-0
dimethyl 4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-1,3-benzenedicarboxylate

: 1556953-96-8
(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

3: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

6: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

7: sodium hydride / N,N-dimethyl-formamide / 15 h / 23 - 50 °C / Inert atmosphere

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; borane-THF; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ml4005123

Reference yield:

: 377082-05-8
dimethyl 4-trifluoromethanesulfonyl-oxy-1,3-benzenedicarboxylate

: 1556953-96-8
(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 23 - 90 °C / Inert atmosphere

2: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

3: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

4: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

5: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

6: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

7: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

8: sodium hydride / N,N-dimethyl-formamide / 15 h / 23 - 50 °C / Inert atmosphere

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ml4005123