(2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol

Base Information

• Chemical Name: (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol
• CAS No.: 872548-42-0
• Molecular Formula: C₄₁H₅₃N₅O₇Si
• Molecular Weight: 755.987
• Mol file: 872548-42-0.mol

Synonyms:(2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol

Chemical Property of (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol

There total 1 articles about (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine (253586-22-0) → (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol (872548-42-0)

Guidance literature:

With methylamine; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9

Reference yield: 98.0%

(2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol (872548-42-0) + methyl iodide (74-88-4) → 5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine (872548-44-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 120h;

DOI:10.1002/hlca.200590209

Reference yield: 88.0%

acetic anhydride (108-24-7) + (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxymethoxy-tetrahydro-furan-3-ol (872548-42-0) → 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine (312709-86-7)

Guidance literature:

With dmap; In pyridine; at 20 ℃; for 0.5h;

DOI:10.1002/hlca.200590209

upstream raw materials:

N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine

Downstream raw materials:

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine

5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine

5'-O-(4,4'-dimethoxytrityl)-N⁶-{{{2-[(triisopropylsilyl)oxy]benzyl}oxy}carbonyl}-2'-O-{[(triisopropylsilyloxy)methyl]adenosine}

5'-O-(4,4'-dimethoxytrityl)-N⁶-{{{2-[(triisopropylsilyl)oxy]benzyl}oxy}carbonyl}-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)