(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

Base Information

Chemical Name:(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine
CAS No.:221341-55-5
Molecular Formula:C₃₂H₂₈INO₂
Molecular Weight:585.484
Hs Code.:

Synonyms:(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

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Technology Process of (2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

There total 4 articles about (2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221341-48-6
Acetic acid (R)-1-[(S)-2-phenyl-1-(9-phenyl-9H-fluoren-9-ylamino)-ethyl]-allyl ester

: 221341-55-5
(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

: Acetic acid (2S,3S,4R)-2-benzyl-4-iodo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidin-3-yl ester

Guidance literature:: With water; iodine; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; for 3h; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1039/a809083a

Reference yield:

: 221341-48-6
Acetic acid (R)-1-[(S)-2-phenyl-1-(9-phenyl-9H-fluoren-9-ylamino)-ethyl]-allyl ester

: 221341-55-5
(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

Guidance literature:: With iodine; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; at 20 ℃;
DOI:10.1016/j.bmcl.2005.06.051

Reference yield:

: 5-phenyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pent-1-en-3-one

: 221341-55-5
(2S,3S,4S)-3-acetoxy-2-benzyl-4-iodo-N-(9-phenylfluoren-9-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: (S)-BINAL / tetrahydrofuran / -78 °C

2: Et₃N / CH₂Cl₂ / 20 °C

3: I₂; aq. NaHCO₃ / tetrahydrofuran; diethyl ether / 20 °C

With (S)-BINAL; iodine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2005.06.051