1-(4-chlorophenyl)ethan-1-imine

Base Information

• Chemical Name: 1-(4-chlorophenyl)ethan-1-imine
• CAS No.: 128720-50-3
• Molecular Formula: C₈H₈ClN
• Molecular Weight: 153.611
• Mol file: 128720-50-3.mol

Synonyms:1-(4-chlorophenyl)ethan-1-imine

Chemical Property of 1-(4-chlorophenyl)ethan-1-imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)ethan-1-imine

There total 6 articles about 1-(4-chlorophenyl)ethan-1-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Cyanochlorobenzene (623-03-0) + methyllithium (917-54-4) → 1-(4-chlorophenyl)ethan-1-imine (128720-50-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - -40 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201608329

Reference yield: 77.0%

4-chloroacetophenone oxime (1956-39-4) → 1-(4-chlorophenyl)ethan-1-imine (128720-50-3)

Guidance literature:

With carbon monoxide; dodecacarbonyl-triangulo-triruthenium; In benzene; at 100 ℃; for 4h; under 15200 Torr;

Reference yield:

p-chloro-(R,S)-1-phenylethylamine (35588-60-4) → (R)-1-(4-chlorophenyl)ethylamine (27298-99-3) + 1-(4-chlorophenyl)ethan-1-imine (128720-50-3)

Guidance literature:

With borane-ammonia complex; monoamine oxidase variant D₉ from Aspergillus niger; In dimethyl sulfoxide; at 37 ℃; for 24h; pH=9; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.bmc.2017.07.023

upstream raw materials:

4-chloroacetophenone oxime

acetonitrile

para-chlorobenzoic acid

1-azido-1-(p-chlorophenyl)ethane

Downstream raw materials:

para-chloroacetophenone

1-(4-chlorophenyl)ethenylacetamide

N-(1-(4-chlorophenyl)ethylidene)aniline

Refernces

• 1、 -. "CATALYTIC PREPARATION OF ENAMIDES FROM ALKYL AZIDES AND ACYL DONORS". Paragraph 0082-0083. . Retrieved 2016/10/10.
• 2、 Han, Junghoon,Jeon, Mina,Pak, Han Kyu,Rhee, Young Ho,Park, Jaiwook. "Exploiting the Nucleophilicity of N-H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides". supporting information. p. 2769 - 2774. Retrieved 2016/02/18.