2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt

Base Information

• Chemical Name: 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt
• CAS No.: 1374667-63-6
• Molecular Formula: C₁₁H₁₂F₂N₂*ClH
• Molecular Weight: 246.687

Synonyms:2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt

Chemical Property of 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt

Chemical Property:

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Technology Process of 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt

There total 1 articles about 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane-2-carboxylic acid tert-butyl ester (1374667-62-5) → 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt (1374667-63-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 7h;

Reference yield: 28.45%

3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbaldehyde (1254982-03-0) + 2-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane hydrochloride salt (1374667-63-6) → 2-[[3-(cyclopropylmethyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]methyl]-5-(2,4-difluorophenyl)-2,5-diazabicyclo[4.1.0]heptane (cis) (1374667-99-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

upstream raw materials:

5-(2,4-difluoro-phenyl)-2,5-diaza-bicyclo[4.1.0]heptane-2-carboxylic acid tert-butyl ester

Downstream raw materials:

2-[[3-(cyclopropylmethyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]methyl]-5-(2,4-difluorophenyl)-2,5-diazabicyclo[4.1.0]heptane (cis)

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