Technology Process of 3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbaldehyde
There total 10 articles about 3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium periodate; osmium(VIII) oxide;
In
1,4-dioxane; water; tert-butyl alcohol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: copper(l) iodide / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C
2.2: 1 h / 20 °C
3.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / microwave irradiation
4.1: triethylamine / dichloromethane / 0.33 h / 0 °C
5.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / microwave irradiation
6.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 0.22 h / 150 °C / microwave irradiation
7.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; trichlorophosphate;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C
1.2: 1 h / 20 °C
2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / microwave irradiation
3.1: triethylamine / dichloromethane / 0.33 h / 0 °C
4.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / microwave irradiation
5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 0.22 h / 150 °C / microwave irradiation
6.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;
