trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate

Base Information

• Chemical Name: trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate
• CAS No.: 132455-52-8
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 132455-52-8.mol

Synonyms:trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate

Chemical Property of trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate

There total 4 articles about trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(αR,βS)-2,3-epoxy-4'-methyl-3-phenylpropiophenone (32046-97-2,32157-66-7,132490-25-6) → (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid p-tolyl ester (132455-52-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 16h; Heating;

DOI:10.1016/S0040-4039(00)97101-6

Reference yield: 35.0%

benzaldehyde (100-52-7) + (4-methylphenoxycarbonylmethyl)triphenylbismuthonium tetrafluoroborate → trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate (132455-52-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo990690t

Reference yield:

trans-1-(p-methylphenyl)-3-phenyl-2,3-epoxy-1-propanone (32157-66-7,32046-97-2,132490-25-6) → trans-4-methylphenyl 2,3-epoxy-3-phenylpropanoate (132455-52-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 16h; Heating;

DOI:10.1016/S0040-4039(00)97101-6

upstream raw materials:

(αR,βS)-2,3-epoxy-4'-methyl-3-phenylpropiophenone

(E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one

trans-1-(p-methylphenyl)-3-phenyl-2,3-epoxy-1-propanone

benzaldehyde

Refernces

• 1、 Baures,Eggleston,Flisak,Gombatz,Lantos,Mendelson,Remich. "An efficient asymmetric synthesis of substituted phenyl glycidic esters". . p. 6501 - 6504. Retrieved 2007/10/02.