tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

Base Information

Chemical Name:tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]
CAS No.:807341-92-0
Molecular Formula:C₆₈H₈₄N₆O₁₁
Molecular Weight:1161.45
Hs Code.:

tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

Synonyms:tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

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Chemical Property of tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

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Technology Process of tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

There total 7 articles about tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: dibenzyl {{5-{{{3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate] hydrochloride

: 349559-92-8
3-[3-(benzyloxycarbonylamino)propyl]-5-[3-(tert-butoxycarbonylamino)propyl]benzoic acid

: 807341-92-0
tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

Guidance literature:: 3-[3-(benzyloxycarbonylamino)propyl]-5-[3-(tert-butoxycarbonylamino)propyl]benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -20 ℃; for 3h;

dibenzyl {{5-{{{3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate] hydrochloride; With triethylamine; In methanol; dichloromethane; at -20 - 20 ℃;
DOI:10.1002/hlca.200690246

Reference yield:

: 870177-64-3
ethyl 3-bromo-5-{3-{[(benzyloxy)carbonyl]amino}propyl}benzoate

: 807341-92-0
tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

Guidance literature:: Multi-step reaction with 6 steps

1.1: 9-BBN / toluene / 12 h / 20 °C

1.2: 86 percent / aq. KOH / Pd(PPh₃)4 / toluene / 14 h / 100 °C

2.1: 81 percent / LiAlH₄ / tetrahydrofuran / 8.5 h / cooling

3.1: 92 percent / H₂; cyclohexa-1,4-diene / Pd/C / ethanol; ethyl acetate / 4 h / 20 °C / 2250.18 Torr

4.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / -30 °C

4.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

5.1: 96 percent / aq. HCl / tetrahydrofuran / 0 - 20 °C

6.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / 3 h / -20 °C

6.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; cyclohexa-1,4-diene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene; 1.2: Suzuki-Miyaura cross-coupling;
DOI:10.1002/hlca.200690246

Reference yield:

: 807341-84-0
benzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]dipropane-3,1-diyl}bis[carbamate]

: 807341-92-0
tribenzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]bis(propane-3,1-diyliminocarbonylbenzene-5,1,3-triyldipropane-3,1-diyl)}tetrakis[carbamate]

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / H₂; cyclohexa-1,4-diene / Pd/C / ethanol; ethyl acetate / 4 h / 20 °C / 2250.18 Torr

2.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / -30 °C

2.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

3.1: 96 percent / aq. HCl / tetrahydrofuran / 0 - 20 °C

4.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / 3 h / -20 °C

4.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; cyclohexa-1,4-diene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1002/hlca.200690246