N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

Base Information

Chemical Name:N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine
CAS No.:1232222-46-6
Molecular Formula:C₂₂H₂₂N₈O
Molecular Weight:414.47
Hs Code.:

Synonyms:N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

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Chemical Property of N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

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Technology Process of N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

There total 7 articles about N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1232225-35-2
(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine

: 620-23-5
m-tolyl aldehyde

: 1232222-46-6
N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

Guidance literature:: acetic acid; In ethanol; at 1 - 30 ℃; for 3h;

Reference yield:

: 62846-82-6
ethyl pyrimidine-4-carboxylate

: 1232222-46-6
N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / 18-crown-6 ether / tetrahydrofuran / 0.17 h / 1 - 30 °C

1.2: 1 h / 0 - 60 °C

1.3: 14 h / Cooling with ice

2.1: triethylamine / dichloromethane / 3 h / 1 - 30 °C

3.1: sodium methylate / methanol / 1 h / 50 °C

4.1: pyridine; trichlorophosphate / toluene / 5 h / 90 °C

5.1: 1,4-dioxane / 3 h / 1 - 30 °C

6.1: hydrazine hydrate / 1,4-dioxane / 14 h / 90 °C

7.1: acetic acid / ethanol / 3 h / 1 - 30 °C

With pyridine; potassium tert-butylate; sodium methylate; hydrazine hydrate; triethylamine; trichlorophosphate; 18-crown-6 ether; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1232225-30-7
methyl 5-amino-3-pyrimidin-4-yl-pyrazole-1-carboxylate

: 1232222-46-6
N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 3 h / 1 - 30 °C

2: sodium methylate / methanol / 1 h / 50 °C

3: pyridine; trichlorophosphate / toluene / 5 h / 90 °C

4: 1,4-dioxane / 3 h / 1 - 30 °C

5: hydrazine hydrate / 1,4-dioxane / 14 h / 90 °C

6: acetic acid / ethanol / 3 h / 1 - 30 °C

With pyridine; sodium methylate; hydrazine hydrate; triethylamine; trichlorophosphate; acetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;