Ethyl 4-pyrimidinecarboxylate

Base Information

• Chemical Name: Ethyl 4-pyrimidinecarboxylate
• CAS No.: 62846-82-6
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2933599090
• Mol file: 62846-82-6.mol

Synonyms:pyrimidine-6-carboxylic acid ethyl ester;ethylpyrimidine-4-carboxylate;Pyrimidin-4-carbonsaeure-aethylester;pyrimidine-4-carboxylic acid ethyl ester;4-ethoxycarbonyl-pyrimidine;Ethyl 4-pyrimidinecarboxylate;

Chemical Property of Ethyl 4-pyrimidinecarboxylate

Chemical Property:

• Vapor Pressure: 0.0383mmHg at 25°C
• Melting Point: 37.0 to 41.0 °C
• Refractive Index: 1.508
• Boiling Point: 240.3 °C at 760 mmHg
• PKA: -0.76±0.10(Predicted)
• Flash Point: 99.1 °C
• PSA: 52.08000
• Density: 1.167 g/cm³
• LogP: 0.65330
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl4-Pyrimidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-pyrimidinecarboxylate

There total 1 articles about Ethyl 4-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrimidine-2-carboxylic acid (31519-62-7) + ethanol (64-17-5) → ethyl pyrimidine-4-carboxylate (62846-82-6)

Guidance literature:

With sulfuric acid;

Reference yield: 95.0%

ethyl pyrimidine-4-carboxylate (62846-82-6) → pyrimidine-4-carboxamide (28648-86-4)

Guidance literature:

With ammonia; magnesium methanolate; In methanol; at 80 ℃; for 24h; under 1275.13 Torr; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.05.075

Reference yield: 80.0%

ethyl pyrimidine-4-carboxylate (62846-82-6) + phenylmagnesium chloride (100-59-4) → phenyl(4-pyrimidinyl)methanone (68027-80-5)

Guidance literature:

In tetrahydrofuran; -80 deg C to rt;

DOI:10.3987/COM-95-7248

upstream raw materials:

pyrimidine-2-carboxylic acid

ethanol

Downstream raw materials:

pyrimidine-4-carboxamide

phenyl(4-pyrimidinyl)methanone

N-(3-methyl-benzylidene)-N'-(7-morpholin-4-yl-2-pyrimidin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

pyrimidine-4-carboxylic acid hydrazide