N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide

Base Information

• Chemical Name: N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide
• CAS No.: 16947-23-2
• Molecular Formula: C₁₇H₁₇N₅O₄
• Molecular Weight: 355.353
• Mol file: 16947-23-2.mol

Synonyms:N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide

Chemical Property of N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide

There total 5 articles about N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-(2-((2-hydrazinyl-2-oxoethyl)amino)-2-oxoethyl)nicotinamide (16947-17-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide (16947-23-2)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.3390/molecules23040761

Reference yield:

3-pyridinecarbonyl chloride (10400-19-8) → N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide (16947-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 23 h / -20 - 20 °C

2: hydrazine hydrate / methanol / 3 h / Reflux

3: ethanol / 8 h / Reflux

With hydrazine hydrate; In methanol; ethanol; dichloromethane;

DOI:10.3390/molecules23040761

Reference yield:

methyl 2-(2-(nicotinamido)acetamido)acetate → N-(2-(2-(2-(4-hydroxybenzylidene)hydrazinyl)-2-oxoethylamino)-2-oxoethyl)nicotinamide (16947-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 3 h / Reflux

2: ethanol / 8 h / Reflux

With hydrazine hydrate; In methanol; ethanol;

DOI:10.3390/molecules23040761

upstream raw materials:

N-(2-((2-hydrazinyl-2-oxoethyl)amino)-2-oxoethyl)nicotinamide

4-hydroxy-benzaldehyde

3-pyridinecarbonyl chloride

nicotinic acid