(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Base Information

Chemical Name:(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
CAS No.:1384958-41-1
Molecular Formula:C₃₂H₄₃N₅O₃
Molecular Weight:545.725
Hs Code.:

Synonyms:(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

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Chemical Property of (1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

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Technology Process of (1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

There total 9 articles about (1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 389621-81-2
[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

: 1384958-41-1
(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

2.1: toluene / 2.5 h / Reflux

3.1: acetic acid; iron / 4 h / 20 - 85 °C

3.2: pH 9 - 10

4.1: dichloromethane / 72 h / 20 °C

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

5.2: pH 3.5

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.83 h / 20 °C

6.2: 1.5 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 5 h / 65 °C / sealed tube

8.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1384958-71-7
(1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(2-(dimethylamino)ethylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

: 1384958-41-1
(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(2-(dimethylamino)ethylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide; With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 1384958-41-1
(1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 4 h / 110 °C

2.1: sodium periodate / water; tetrahydrofuran / 15 h / 0 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

4.1: toluene / 2.5 h / Reflux

5.1: acetic acid; iron / 4 h / 20 - 85 °C

5.2: pH 9 - 10

6.1: dichloromethane / 72 h / 20 °C

7.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

7.2: pH 3.5

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.83 h / 20 °C

8.2: 1.5 h / 20 °C

9.1: triethylamine / N,N-dimethyl-formamide / 5 h / 65 °C / sealed tube

10.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; sodium periodate; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;