7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Base Information

Chemical Name:7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS No.:1215225-88-9
Molecular Formula:C₂₃H₁₉F₃N₈OS
Molecular Weight:512.518
Hs Code.:

Synonyms:7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

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Chemical Property of 7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

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Technology Process of 7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

There total 7 articles about 7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: C₁₆H₁₄ClF₃N₆OS

: 613-92-3
N-hydroxybenzamidine

: 1215225-88-9
7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: With pyridine; at 120 ℃; for 4h;

Reference yield:

: 1215221-89-8
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester

: 1215225-88-9
7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

3.1: pyridine / 4 h / 120 °C

With pyridine; oxalyl dichloride; water; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 68746-74-7
4-oxo-6-propyl-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester

: 1215225-88-9
7-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 16 h / Reflux

2.1: triethylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

3.2: pH 3

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

5.1: pyridine / 4 h / 120 °C

With pyridine; oxalyl dichloride; water; triethylamine; lithium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;