(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Base Information

Chemical Name:(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane
CAS No.:122948-78-1
Molecular Formula:C₁₉H₃₇BrO₂Si
Molecular Weight:405.491
Hs Code.:

Synonyms:(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Suppliers and Price of (1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

There total 23 articles about (1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 122948-77-0
(1R,2R,4R)-4-(1-propyn-1-yl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

: 122948-78-1
(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: With N-Bromosuccinimide; Schwartz's reagent;
DOI:10.1021/jo00279a004

Reference yield:

: 118207-39-9
(4R,5S)-5-ethenyl-4-methoxytetrahydro-2H-pyran-2-one

: 122948-78-1
(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: Multi-step reaction with 11 steps

1: Et₃N / CH₂Cl₂ / 1.) -78 deg C, 90 min, 2.) 0 deg C, 60 min

2: toluene / 76 h / Heating

3: 1 N HCl / toluene; tetrahydrofuran / 3 h / Ambient temperature

4: diethyl ether; ethyl acetate

5: 1.) a) BH₃, 2.) 30percent H₂O₂, 3 N NaOH / 1.) a) THF, -78 deg C, 30 min, b) 0 deg C, 90 min, 2.) THF, RT, 3 h

6: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

7: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

8: 89 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.17 h / -78 °C

9: 1.) t-BuOK / 1.) THF, -78 deg C, 10 min, 2.) a) -78 deg C, 10 h, b) -20 deg C, 10 h

10: 1.) n-BuLi / 1.) THF, from -78 to -35 deg C, 2 h, 2.) from -78 deg C to RT, 14 h

11: 1.) Cp₂ZrHCl, 2.) N-bromosuccinimide / 1.) benzene, 35-40 deg C, 70 min, 2.) RT, 25 min

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; Schwartz's reagent; n-butyllithium; oxalyl dichloride; borane; potassium tert-butylate; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ja00170a024

Reference yield:

: 118207-41-3
(1R,3R)-3-methoxycyclohex-4-enecarboxylic acid

: 122948-78-1
(1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; ethyl acetate

2: 1.) a) BH₃, 2.) 30percent H₂O₂, 3 N NaOH / 1.) a) THF, -78 deg C, 30 min, b) 0 deg C, 90 min, 2.) THF, RT, 3 h

3: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

4: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

5: 89 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.17 h / -78 °C

6: 1.) t-BuOK / 1.) THF, -78 deg C, 10 min, 2.) a) -78 deg C, 10 h, b) -20 deg C, 10 h

7: 1.) n-BuLi / 1.) THF, from -78 to -35 deg C, 2 h, 2.) from -78 deg C to RT, 14 h

8: 1.) Cp₂ZrHCl, 2.) N-bromosuccinimide / 1.) benzene, 35-40 deg C, 70 min, 2.) RT, 25 min

With sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; Schwartz's reagent; n-butyllithium; oxalyl dichloride; borane; potassium tert-butylate; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/ja00170a024