(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate
CAS No.:1448805-84-2
Molecular Formula:C₂₇H₂₆FNO₇S₂
Molecular Weight:559.636
Hs Code.:

Synonyms:(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

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Technology Process of (S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

There total 4 articles about (S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 39082-53-6
1,1-bis(phenylsulfonyl)ethylene

: 862907-21-9
tert-butyl 3-fluoro-2-oxoindoline-1-carboxylate

: 1448805-84-2
(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

Guidance literature:: With C₂₇H₂₈F₂N₄OS; In chloroform; at 20 ℃; for 0.416667h; Reagent/catalyst; Solvent; Time; enantioselective reaction; Molecular sieve; Sealed tube;
DOI:10.1039/c3ob41267a

Reference yield:

: 39082-53-6
1,1-bis(phenylsulfonyl)ethylene

: 862907-21-9
tert-butyl 3-fluoro-2-oxoindoline-1-carboxylate

: 1448805-84-2
(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

: (R)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

Guidance literature:: With C₂₆H₂₆F₂N₄S; In toluene; at 20 ℃; for 0.166667h; Solvent; Time; Overall yield = > 95 %; enantioselective reaction; Sealed tube;
DOI:10.1039/c3ob41267a

Reference yield:

: 214610-10-3
N-boc-2-oxyindole

: 1448805-84-2
(S)-tert-butyl 3-(2,2-bis(phenylsulfonyl)ethyl)-3-fluoro-2-oxoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.25 h / 0 °C / Inert atmosphere

2.1: C₂₇H₂₈F₂N₄OS / chloroform / 0.42 h / 20 °C / Molecular sieve; Sealed tube

With C₂₇H₂₈F₂N₄OS; sodium hydride; In tetrahydrofuran; chloroform;
DOI:10.1039/c3ob41267a