214610-10-3

Basic information

• Product Name: tert-butyl 2-oxo-2,3-dihydroindole-1-carboxylate
• Synonyms: tert-butyl 2-oxo-2,3-dihydroindole-1-carboxylate;tert-Butyl 2-oxoindoline-1-carboxylate;2-Oxo-2,3-Dihydro-Indole-1-Carboxylic Acid Tert-Butyl Ester(WX625020)
• CAS NO: 214610-10-3
• Molecular Formula: C₁₃H₁₅NO₃
• Molecular Weight: 233
• Mol File: 214610-10-3.mol
• Article Data: 33

Chemical Properties

• Melting Point: 65-68 °C(Solv: hexane (110-54-3))
• Boiling Point: 323.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.206±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.59±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-oxo-2,3-dihydroindole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-oxo-2,3-dihydroindole-1-carboxylate(214610-10-3)
• EPA Substance Registry System: tert-butyl 2-oxo-2,3-dihydroindole-1-carboxylate(214610-10-3)

Safety Data

• Hazardous Substances Data: 214610-10-3(Hazardous Substances Data)

Upstream product

• 58377-40-5 tert-butyl N-hydroxy-N-phenylcarbamate 
• 1026846-93-4 but-3-enoyl-furan-2-yl-carbamic acid tert-butyl ester 
• 75400-67-8 indole-1-carboxylic acid tert-butyl ester 
• 59-48-3 2-oxoindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1387581-35-2 C₃₀H₂₇Br₂NO₄ 
• 1387581-29-4 C₃₀H₂₉NO₄ 
• 1387581-33-0 C₃₀H₂₇Cl₂NO₄ 
• 1387581-36-3 C₃₂H₃₃NO₄ 
• 1387581-30-7 C₃₀H₂₇F₂NO₄ 
• 1387581-32-9 C₃₀H₂₇Cl₂NO₄ 
• 1387581-34-1 C₃₀H₂₇Br₂NO₄ 
• 1387581-31-8 C₃₀H₂₇F₂NO₄ 
• 1332461-49-0 (E)-3-((5-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)iso-xazol-3-yl)methylene)indolin-2-one 

Relevant articles and documents

Oxoarylation of ynamides with N-aryl hydroxamic acids

Ynamides are electron-rich alkynes with unique reactivities and act as flexible building blocks in organic synthesis. Therefore, the investigation for transformation of ynamides with exceptional selectivity and efficiency is attractive and interesting. He

Highly Stereoselective [4+2] and [3+2] Spiroannulations of 2-(2-Oxoindolin-3-ylidene)acetic Esters Catalyzed by Bifunctional Thioureas

A new Michael-Michael cascade reaction between 2-(2-oxoindolin-3-ylidene)acetic esters 1 and nitroenoates 2, catalyzed by bifunctional thioureas, is investigated. The combination of the two Michael reactions results in a novel and facile [4+2] or [3+2] spiroannulation process, which is characterized by the following features: 1) two carbon-carbon bonds and four stereocenters, including a quaternary spiro carbon, are formed under mild conditions; 2) an unprecedented and stereochemically defined substitution pattern on the spirocarbocyclic unit is obtained; 3) the double-bond configuration of the donor-acceptor nitroenoate 2 determines the absolute configuration of the spiro center, whereas the remaining stereocenters are formed under control of the catalyst. The effect on the final stereochemical outcome of structural variations of each starting material, catalyst, and experimental conditions is analyzed in detail. In particular, the use of specifically designed chiral nitroenoates enables diverse polyfunctional spirocyclohexane derivatives containing six consecutive stereogenic centers to be constructed. To our knowledge, this is the first asymmetric organocatalytic strategy enabling both five- and six-membered β-nitro spirocarbocyclic oxindoles.

Studies on protection of oxindoles

Protection of amide nitrogen of oxindole and methyloxindole using Boc and Z-groups has been described. Sodium carbonate was found to be an effective base for these protections.

NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

The present invention provides novel poly(ADP-ribose) polymerase (PARP) inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods for the treatment, prevention and/or amelioration of PARP mediated diseases or disorders using them. In particular, the compounds described herein are useful for the treatment of carcinoma of the breast, ovarian cancer, carcinoma of the liver, carcinoma of the lung, small cell lung cancer, esophageal cancer, gall bladder cancer, pancreatic cancer and stomach cancer.