1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane
CAS No.:171416-77-6
Molecular Formula:C₂₆H₃₆N₄O₈S₂
Molecular Weight:596.726
Hs Code.:

Synonyms:1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

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Chemical Property of 1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

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Technology Process of 1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

There total 4 articles about 1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 134448-29-6
1,7-bis(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane

: 79-08-3
bromoacetic acid

: 171416-77-6
1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: With potassium hydroxide; sodium carbonate; In methanol; 45 deg C, 6 h; 65 deg C, overnight;
DOI:10.1055/s-1995-4043

Reference yield:

: 52667-88-6
cyclen tetratosylate

: 171416-77-6
1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / H₂SO₄ / 48 h / 100 °C

2: 94 percent / pyridine / 4 h / 20 °C

3: 76 percent / KOH; Na₂CO₃ / methanol / 45 - 65 °C

With pyridine; potassium hydroxide; sulfuric acid; sodium carbonate; In methanol; 1: Hydrolysis / 2: Tosylation / 3: Alkylation;
DOI:10.1080/00397919908085901

Reference yield:

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 171416-77-6
1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / 4 h / 20 °C

2: 76 percent / KOH; Na₂CO₃ / methanol / 45 - 65 °C

With pyridine; potassium hydroxide; sodium carbonate; In methanol; 1: Tosylation / 2: Alkylation;
DOI:10.1080/00397919908085901