dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

Base Information

Chemical Name:dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate
CAS No.:84080-47-7
Molecular Formula:C₃₇H₄₄N₂O₉Si
Molecular Weight:688.85
Hs Code.:

dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<methoxycarbonyl-(t-butyl)dimethylsilyloxymethyl>malonate

Synonyms:dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

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Chemical Property of dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

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Technology Process of dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

There total 7 articles about dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: dibenzyl 2-(4-formyl-2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>malonate

: 84080-47-7
dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

Guidance literature:: With Wilkinson's catalyst; In benzene; for 2h; Heating;
DOI:10.1002/hlca.19820650508

Reference yield:

: 31661-15-1
dibenzyl aminomalonate

: 84080-47-7
dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

Guidance literature:: Multi-step reaction with 8 steps

1: MgSO₄ / CH₂Cl₂ / 6 h / Ambient temperature

2: 40 percent / imidazole / dimethylformamide / 4 h / 25 °C

3: benzene / 18 h / Heating; Dean-Stark strap

4: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

5: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

6: pyridine / CH₂Cl₂ / 2 h

7: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

8: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

With pyridine; 1H-imidazole; Wilkinson's catalyst; dimethylsulfide; hydrogen sulfide; magnesium sulfate; ozone; triethylamine; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.19820650508

Reference yield:

: 84080-31-9
dibenzyl 2-amino-2-(hydroxy-methoxycarbonylmethyl)malonate

: 84080-47-7
dibenzyl 2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-malonate

Guidance literature:: Multi-step reaction with 7 steps

1: 40 percent / imidazole / dimethylformamide / 4 h / 25 °C

2: benzene / 18 h / Heating; Dean-Stark strap

3: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

4: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

5: pyridine / CH₂Cl₂ / 2 h

6: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

7: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

With pyridine; 1H-imidazole; Wilkinson's catalyst; dimethylsulfide; hydrogen sulfide; ozone; triethylamine; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.19820650508