Technology Process of tert-butyl 12-(3-{bis[2-(diphenylphosphino)ethyl]amino}-3-oxopropyl)-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
There total 5 articles about tert-butyl 12-(3-{bis[2-(diphenylphosphino)ethyl]amino}-3-oxopropyl)-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
12-{[(2-tert-butoxy-2-oxoethyl)amino]carbonyl}-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazapentadecan-15-oic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 23 ℃;
for 0.5h;
bis[(2-diphenylphosphino)ethyl]amine hydrochloride;
In
dichloromethane;
at 23 ℃;
for 16h;
DOI:10.1055/s-0033-1339340
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 48 h / 23 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 23 °C
2.2: 16 h / 23 °C
With
5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; ethyl acetate;
DOI:10.1055/s-0033-1339340
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chloroformic acid ethyl ester; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 10 °C
1.2: 16 h / -15 - 23 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 23 °C
2.2: 16 h / 23 °C
3.1: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 48 h / 23 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 23 °C
4.2: 16 h / 23 °C
With
5%-palladium/activated carbon; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339340
![12-{[(2-tert-butoxy-2-oxoethyl)amino]carbonyl}-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazapentadecan-15-oic acid](/Databaselist/images/loading.webp)
