(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

Base Information

Chemical Name:(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione
CAS No.:173242-81-4
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

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Chemical Property of (4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

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Technology Process of (4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

There total 4 articles about (4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 930-88-1
N-methylmaleimide

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 173167-55-0
(2S,3R)-3,5-diphenylmorpholinone

: 173242-81-4
(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

: (4R,6aR,9aS,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

Guidance literature:: In xylene; Heating;
DOI:10.1016/0957-4166(95)00321-F

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 173242-81-4
(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 33percent HBr/AcOH

2: 1.) 0.2 M NaOAc/AcOH, 2.) H₂ / 2.) Pd/C / 2.) AcOEt

3: 29 percent / mol. sieves / xylene / Heating

With molecular sieve; hydrogen bromide; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; In xylene;
DOI:10.1016/0957-4166(95)00321-F

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 173242-81-4
(4R,6aS,9aR,9bS)-8-Methyl-4,9b-diphenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / aq. NaOH / dioxane

2: 81 percent / 33percent HBr/AcOH

3: 1.) 0.2 M NaOAc/AcOH, 2.) H₂ / 2.) Pd/C / 2.) AcOEt

4: 29 percent / mol. sieves / xylene / Heating

With sodium hydroxide; molecular sieve; hydrogen bromide; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; xylene;
DOI:10.1016/0957-4166(95)00321-F