4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

Base Information

Chemical Name:4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide
CAS No.:1261576-81-1
Molecular Formula:C₂₅H₂₄ClN₃O₃S₂
Molecular Weight:514.069
Hs Code.:
Mol file:1261576-81-1.mol

Synonyms:(4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl) phenoxy)thiophene-2-sulfonamide)

Suppliers and Price of 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide
2mg
$ 65.00

Sigma-Aldrich
B355252 ≥98% (HPLC)
10mg
$ 61.60

Sigma-Aldrich
B355252 ≥98% (HPLC)
50mg
$ 249.00

DC Chemicals
B355252
1G
$ 1200.00

DC Chemicals
B355252
250 mg
$ 600.00

DC Chemicals
B355252
100 mg
$ 350.00

Cayman Chemical
B355252
25mg
$ 120.00

Cayman Chemical
B355252
10mg
$ 50.00

Cayman Chemical
B355252
5mg
$ 30.00

Cayman Chemical
B355252
50mg
$ 210.00

Total 12 raw suppliers

Chemical Property of 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

Chemical Property:

Melting Point:142-144 °C
Boiling Point:718.4±70.0 °C(Predicted)
PKA:10.16±0.50(Predicted)
Density:1.370±0.06 g/cm3(Predicted)
Storage Temp.:?20°C
Solubility.:DMSO: soluble10mg/mL, clear

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25-36/37/38
Safety Statements: 26-36/37/39-45

MSDS Files:

Useful:

Description B355252 is a neuroprotective agent. It potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM). B355252 inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner and inhibits glutamate-induced decreases in GSH levels and increases in Bax levels, intracellular accumulation of calcium, and production of reactive oxygen species (ROS) in HT-22 cells when used at a concentration of 8 μM. It also inhibits decreases in cell viability, increases in ROS production, and mitochondrial membrane depolarization induced by 6-hydroxydopamine (6-OHDA; ) in HT-22 cells, an in vitro model of Parkinson’s disease.

Technology Process of 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

There total 4 articles about 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1261576-78-6
tert-butyl 4-(3-(3-chloro-5-(N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)sulfamoyl)thiophen-2-yloxy)phenyl)piperazine-1-carboxylate

: 1261576-81-1
(4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl) phenoxy)thiophene-2-sulfonamide)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.028

Reference yield:

: 118-31-0
(naphth-1-yl)methylamine

: 1261576-81-1
(4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl) phenoxy)thiophene-2-sulfonamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium hydride; caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1261576-75-3
4,5-dichloro-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

: 1261576-81-1
(4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl) phenoxy)thiophene-2-sulfonamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium hydride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;