1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 198627-86-0
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.351
• Mol file: 198627-86-0.mol

Synonyms:N-boc-3-piperazin-1-yl-phenol;

Chemical Property of 1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 435.8±40.0 °C(Predicted)
• PKA: 10.33±0.10(Predicted)
• PSA: 53.01000
• Density: 1.167±0.06 g/cm3(Predicted)
• LogP: 2.45220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

1-(3-Hydroxy-phenyl)-piperazine-4-carboxylicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 7 articles about 1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(piperazin-1-yl)phenol (59817-32-2) → 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate (198627-86-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 100.0%

4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (862261-23-2) → 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate (198627-86-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.05.043

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-(piperazin-1-yl)phenol (59817-32-2) + 4-(3-methoxyphenyl)piperazine (16015-71-7) → 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate (198627-86-0)

Guidance literature:

upstream raw materials:

4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

3-(piperazin-1-yl)phenol

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

tert-butyl 4-(3-(2-fluoroethoxy)phenyl)piperazine-1-carboxylate

C₃₀H₃₂ClN₃O₅S₂

tert-butyl 4-(3-(3-chloro-5-(N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)sulfamoyl)thiophen-2-yloxy)phenyl)piperazine-1-carboxylate

1-(3-ethoxyphenyl)piperazine

Refernces

• 1、 -. "PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0310-0311. . Retrieved 2013/10/08.
• 2、 -. "FUSED HETEROCYCLIC COMPOUND". Page/Page column 102. . Retrieved 2011/07/29.