Technology Process of (S)-2-(amino(phenyl)methyl)-5-fluorophenol
There total 2 articles about (S)-2-(amino(phenyl)methyl)-5-fluorophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate;
In
benzene;
at 50 ℃;
for 72h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1002/chem.201101694
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonia / methanol / 16 h / 20 °C / Cooling with ice
2: (R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate / benzene / 72 h / 50 °C / Inert atmosphere; Sealed tube
With
(R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; ammonia; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate;
In
methanol; benzene;
DOI:10.1002/chem.201101694
