4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

Base Information

Chemical Name:4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid
CAS No.:1431773-10-2
Molecular Formula:C₂₈H₂₄N₆O₆
Molecular Weight:540.535
Hs Code.:

Synonyms:4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

There total 5 articles about 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1431773-96-4
methyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoate

: 1431773-10-2
4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 2h;

Reference yield:

: 933190-51-3
8-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1431773-10-2
4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 15.17 h / 0 - 20 °C

2.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Inert atmosphere

3.1: water; lithium hydroxide / 1,4-dioxane; water / 4 h

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

5.2: pH 2

With 1-methyl-1H-imidazole; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1415314-13-4
6-chloro-N-(5,6-dimethoxypyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

: 1431773-10-2
4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Inert atmosphere

2.1: water; lithium hydroxide / 1,4-dioxane; water / 4 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

4.2: pH 2

With 1-methyl-1H-imidazole; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;