2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

Base Information

Chemical Name:2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid
CAS No.:1403381-02-1
Molecular Formula:C₂₆H₃₃NO₅
Molecular Weight:439.552
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

There total 9 articles about 2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1403382-09-1
methyl 2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetate

: 1403381-02-1
2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetate; With water; potassium hydroxide; In ethanol; at 90 ℃; for 1.5h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 53663-39-1
3-methyl-2-bromobenzoic acid

: 1403381-02-1
2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 3 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

3.2: 1 h / Reflux

4.1: perchloric acid / 2 h / -20 °C

5.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / tetrachloromethane / 2 h / Reflux

5.2: Reflux

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C

7.1: dimethyl sulfoxide; sodium chlorite / acetonitrile; water / 72 h / 55 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

9.1: potassium hydroxide; water / ethanol / 1.5 h / 90 °C

9.2: pH 2

With selenium(IV) oxide; sodium chlorite; N-Bromosuccinimide; thionyl chloride; perchloric acid; water; sodium carbonate; dimethyl sulfoxide; triethylamine; HATU; potassium hydroxide; magnesium chloride; 1,1'-azobis(1-cyanocyclohexanenitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 944268-58-0
1-(2-bromo-3-methylphenyl)ethan-1-one

: 1403381-02-1
2-(tert-butoxy)-2-[3-(diethylcarbamoyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

1.2: 1 h / Reflux

2.1: perchloric acid / 2 h / -20 °C

3.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / tetrachloromethane / 2 h / Reflux

3.2: Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C

5.1: dimethyl sulfoxide; sodium chlorite / acetonitrile; water / 72 h / 55 °C

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

7.1: potassium hydroxide; water / ethanol / 1.5 h / 90 °C

7.2: pH 2

With selenium(IV) oxide; sodium chlorite; N-Bromosuccinimide; perchloric acid; water; sodium carbonate; dimethyl sulfoxide; triethylamine; HATU; potassium hydroxide; 1,1'-azobis(1-cyanocyclohexanenitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;