Technology Process of 2-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)phenylamine
There total 5 articles about 2-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)phenylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / N,N-dimethyl-formamide / 19 h / 23 - 80 °C / Inert atmosphere
2.1: sodium cyanoborohydride; acetic acid / methanol / 4 h / 23 °C / Inert atmosphere
2.2: 5 h / 50 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 23 °C / Inert atmosphere
4.1: potassium tert-butylate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere; Microwave irradiation
5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 23 °C / Inert atmosphere
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm4013906
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium tert-butylate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere; Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 23 °C / Inert atmosphere
With
palladium 10% on activated carbon; potassium tert-butylate; hydrogen;
In
methanol; dimethyl sulfoxide;
DOI:10.1021/jm4013906
