(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate
CAS No.:1621164-75-7
Molecular Formula:C₂₇H₃₄N₄O₄
Molecular Weight:478.591
Hs Code.:

Synonyms:(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

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Chemical Property of (R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

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Technology Process of (R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

There total 4 articles about (R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 695-34-1
2-Amino-4-methylpyridine

: 1621165-20-5
(R)-tert-butyl 2-ethynylmorpholine-4-carboxylate

: 1289048-52-7
4-formyl-N,3-dimethylbenzamide

: 1621164-75-7
(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); copper(l) chloride; In toluene; at 140 ℃; for 0.833333h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 7697-28-1
4-bromo-3-methylbenzoic acid

: 1621164-75-7
(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C

2.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: copper(l) chloride; copper(II) bis(trifluoromethanesulfonate) / toluene / 0.83 h / 140 °C / Microwave irradiation; Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 24078-23-7
4-formyl-3-methyl benzoic acid

: 1621164-75-7
(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: copper(l) chloride; copper(II) bis(trifluoromethanesulfonate) / toluene / 0.83 h / 140 °C / Microwave irradiation; Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; In N,N-dimethyl-formamide; toluene;