4-ForMyl-3-Methylbenzoic acid

Base Information

• Chemical Name: 4-ForMyl-3-Methylbenzoic acid
• CAS No.: 24078-23-7
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Hs Code.: 2918300090
• Mol file: 24078-23-7.mol

Synonyms:4-formyl-3-methylbenzoic acid;methyl-4-carboxybenzaldehyde;

Chemical Property of 4-ForMyl-3-Methylbenzoic acid

Chemical Property:

• Boiling Point: 340.5±30.0 °C(Predicted)
• PKA: 3.85±0.10(Predicted)
• PSA: 54.37000
• Density: 1.263±0.06 g/cm3(Predicted)
• LogP: 1.50570

Purity/Quality:

99% ^*data from raw suppliers

4-Formyl-3-methylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Formyl-3-methylbenzoic Acid is used in the synthesis of novel alkylaminomethyl substituted Ph and thienyl derivatives as potent SIPR1 agonists.

Technology Process of 4-ForMyl-3-Methylbenzoic acid

There total 4 articles about 4-ForMyl-3-Methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-butyl 4-formyl-3-methylbenzoate (1187028-45-0) → 4-formyl-3-methyl benzoic acid (24078-23-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2016.03.048

Reference yield: 23.0%

4-bromo-3-methylbenzoic acid (7697-28-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-formyl-3-methyl benzoic acid (24078-23-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 2h; Inert atmosphere;

Reference yield:

4-bromo-3-methylbenzoic acid (7697-28-1) → 4-formyl-3-methyl benzoic acid (24078-23-7)

Guidance literature:

4-bromo-3-methylbenzoic acid; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide; at -78 - 20 ℃; for 2.5h;

upstream raw materials:

tert-butyl 4-formyl-3-methylbenzoate

4-bromo-3-methylbenzoic acid

N,N-dimethyl-formamide

tert-butyl 4-bromo-3-methylbenzoate

Downstream raw materials:

(R)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

(S)-tert-butyl 2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

(2S,5S)-tert-butyl 5-methyl-2-((7-methyl-2-(2-methyl-4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

N-ethyl-4-formyl-3-methylbenzamide