3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

Base Information

Chemical Name:3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester
CAS No.:853076-93-4
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

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Chemical Property of 3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

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Technology Process of 3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

There total 8 articles about 3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 853076-92-3
5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 853076-93-4
3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 21.5h;

Reference yield:

: 497068-68-5
tert-butyl 8-bromo-5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 853076-93-4
3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetone

2: Pd(OAc)2 / various solvent(s)

3: H₂ / Pd/C / ethanol

4: Cs₂CO₃ / dimethylformamide

5: CF₃CO₂H

With palladium diacetate; hydrogen; potassium carbonate; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; acetone; 2: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 853074-91-6
tert-butyl 5-(benzyloxy)-8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 853076-93-4
3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(OAc)2 / various solvent(s)

2: H₂ / Pd/C / ethanol

3: Cs₂CO₃ / dimethylformamide

4: CF₃CO₂H

With palladium diacetate; hydrogen; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028