5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

Base Information

Chemical Name:5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester
CAS No.:853076-94-5
Molecular Formula:C₃₅H₃₈N₂O₆
Molecular Weight:582.697
Hs Code.:

Synonyms:5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

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Chemical Property of 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

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Technology Process of 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

There total 9 articles about 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

: 853076-93-4
3-{5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-l,2,3,4-tetrahydro-isoquinolin-8-yl}-propionic acid methyl ester

: 109-61-5
propoxycarbonyl chloride

: 853076-94-5
5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 10 - 20 ℃; for 15.33h;

Reference yield:

: 497068-68-5
tert-butyl 8-bromo-5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 853076-94-5
5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / acetone

2: Pd(OAc)2 / various solvent(s)

3: H₂ / Pd/C / ethanol

4: Cs₂CO₃ / dimethylformamide

5: CF₃CO₂H

6: Et₃N / CH₂Cl₂

With palladium diacetate; hydrogen; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 853074-91-6
tert-butyl 5-(benzyloxy)-8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 853076-94-5
5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-methoxycarbonyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)2 / various solvent(s)

2: H₂ / Pd/C / ethanol

3: Cs₂CO₃ / dimethylformamide

4: CF₃CO₂H

5: Et₃N / CH₂Cl₂

With palladium diacetate; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028